ea0016p597 | Paediatric endocrinology | ECE2008
Raile Klemens
, Wessel Theda
, Deiss Dorothee
, Mueller Dominik
, Horn Denise
, Riebel Wolfgang
, Ullmann Reinhard
, Klopocki Eva
, Grueters Annette
Objective: MODY5 is caused by abnormalities in the TCF2 gene encoding the transcription factor HNF1β. We investigated cases of MODY5 for the underlying type of TCF2 anomaly.Case presentations: From 623 children and adolescents with diabetes mellitus followed at our diabetes clinic in 2006, 64 were negative for islet cell autoantibodies (GAD, IA-2, ICA) within the first year of diagnosis and out of these, four patients presented clinica...